Register for the next webinar in the Inspired Science Webinar Series and hear Dr. David Sinclair from Harvard Medical School present Next-gen epigenomics to understand why we age

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Watch the recording, available October 6th

Date: September 29th

Time: 11 AM EST

Speaker: David Sinclair, Ph.D., Harvard Medical School

While the genome is relatively constant, the epigenome fluctuates with the environment and over time. Epigenetics studies are thus essential for understanding complex biological process such as aging. However, the process of examining the epigenome is technologically complex. In this webinar, Dr. David Sinclair will discuss how his team is investigating aging-based reprogramming of the epigenome at Harvard Medical School. Dr. Sinclair will describe how his team is applying Dovetail Genomic's technology to mouse models to understand human aging at the molecular level, including loss of epigenetic marks in longevity-related genes. Dr. Sinclair will further discuss how approaches focused at reprogramming the epigenome could offer a path to reversing the aging process.

Highlights include:

  • Emerging tools for epigenetic research
  • How to generate the highest resolution views of genome topology
  • Aging related genes (longevity genes) that have been identified and their role in the aging process
  • Approaches focused at reprogramming the epigenome that are under investigation and may offer a path to reversing the aging process


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David Sinclair, Ph.D. headshot

David Sinclair, Ph.D., A.O
Harvard Medical School

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Insitute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney, in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability and aging. In 1999 he moved to Harvard Medical School and has primarily focused on understanding why we age and the role of protective enzymes called the sirtuins, ,which respond to changing NAD+ levels, exercise, and caloric restriction (CR). His interests include chromatin, energy metabolism, mitochondria, epigenetic reprogramming, exercise, learning and memory, neurodegeneration, and cancer.


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