New Gentle Methyl Conversion Kit Delivers High-Accuracy Profiling from as Little as 100 pg of DNA

New commercial kit brings Nature Communications-validated methylation analysis chemistry to researchers working with low-input and cfDNA samples

CAMBRIDGE, Mass., Feb. 23, 2026 /PRNewswire/ — Ellis Bio, a developer of next-generation epigenomics technologies, today announced the official commercial launch of its SuperMethyl™ Max Bisulfite Conversion Kit, a new and gentle methyl conversion solution designed for highly sensitive methylation detection from low-input and fragile DNA samples. The announcement coincides with the Advances in Genome Biology and Technology (AGBT) General Meeting in Orlando, FL, where Ellis Bio is a contributing sponsor.

The technology underpinning the SuperMethyl™ Max kit is the ultra-mild bisulfite chemistry, first described in Nature Communications, which demonstrated dramatically reduced DNA damage compared to all other bisulfite-based methods and dramatically improved specificity (reducing false methylation calls) compared to enzymatic methods.

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